Human Growth Factors & Cytokines
Recombinant Human NOV





 





		Synonyms :
Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH



		Description :
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins.  The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities.  Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas.  However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression.  Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C.  NOV has also been reported to exert proangiogenic activities.  Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues.  It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).



		Catalog #:
120-26



		Source :
E.coli



		Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by a cell proliferation assay using BALB/c 3T3 cells.  The expected ED50 for this effect is 1.0-2.0 μg/ml


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MQVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M 



		PubMed Link :
NOV+AND+CCN3


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
20μg
$195 
 


 



        Size C
1mg
$3900 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.