NRG3 polyclonal antibody
产品名称： NRG3 polyclonal antibody
英文名称： NRG3 polyclonal antibody
产品编号： PAB7582
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of NRG3.
- Immunogen:
- A synthetic peptide corresponding to human NRG3.
- Sequence:
- C-RNEIQRDSALTK
- Host:
- Goat
- Theoretical MW (kDa):
- 75
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:64000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- NRG-3 in human breast cancers: activation of multiple erbB family proteins.
Hijazi MM, Young PE, Dougherty MK, Bressette DS, Cao TT, Pierce JH, Wong LM, Alimandi M, King CR.Int J Oncol. 1998 Nov;13(5):1061-7.
- Entrez GeneID:
- 10718
- Protein Accession#:
- NP_001010848.2
- Gene Name:
- NRG3
- Gene Alias:
- HRG3,pro-NRG3
- Gene Description:
- neuregulin 3
- Omim ID:
- 605533
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified
- Other Designations:
- neuregulin-3-like polypeptide
- Gene Pathway
- Related Disease