NOD2 polyclonal antibody
产品名称： NOD2 polyclonal antibody
英文名称： NOD2 polyclonal antibody
产品编号： PAB13102
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NOD2.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 16 amino acids of human NOD2.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- NOD2 has no cross-reaction with NOD1.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G.Nature. 2001 May 31;411(6837):599-603.
- 2.
- A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH.Nature. 2001 May 31;411(6837):603-6.
- 3.
- Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.
Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G.J Biol Chem. 1999 May 21;274(21):14560-7.
- Entrez GeneID:
- 64127
- Protein Accession#:
- Q9HC29
- Gene Name:
- NOD2
- Gene Alias:
- ACUG,BLAU,CARD15,CD,CLR16.3,IBD1,NLRC2,NOD2B,PSORAS1
- Gene Description:
- nucleotide-binding oligomerization domain containing 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq
- Other Designations:
- NLR family, CARD domain containing 2,NOD-like receptor C2,OTTHUMP00000164224,caspase recruitment domain family, member 15,caspase recruitment domain protein 15,inflammatory bowel disease protein 1,nucleotide-binding oligomerization domain 2,nucleotide-bin
- Related Disease
- Abscess
- Acquired Hyperostosis Syndrome
- Acute Disease
- Adenocarcinoma
- Anus Diseases
- Arthritis
- Arthritis, Juvenile Rheumatoid
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Arthropathy, Neurogenic
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Atrial Fibrillation
- Autoimmune Diseases
- Bacteremia
- Bacterial Infections
- Behcet Syndrome