PEX19 polyclonal antibody
产品名称： PEX19 polyclonal antibody
英文名称： PEX19 polyclonal antibody
产品编号： PAB4328
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PEX19.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PEX19.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.
Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC.Biochem Biophys Res Commun. 2002 Mar 15;291(5):1180-6.
- 2.
- Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.
Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA.Biochem Biophys Res Commun. 2000 Apr 29;271(1):144-50.
- 3.
- Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.
Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y.Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2116-21.
- Applications
- Western Blot (Tissue lysate)
- The PEX19 polyclonal antibody (Cat # PAB4328) is used in Western blot to detect PEX19 in mouse liver tissue lysate .
- Western Blot (Cell lysate)
- The PEX19 polyclonal antibody (Cat # PAB4328) is used in Western blot to detect PEX19 in Y-79 cell lysate .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with PEX19 polyclonal antibody (Cat # PAB4328) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .
- Entrez GeneID:
- 5824
- Protein Accession#:
- PXF_HUMAN
- Gene Name:
- PEX19
- Gene Alias:
- D1S2223E,HK33,PMP1,PMPI,PXF,PXMP1
- Gene Description:
- peroxisomal biogenesis factor 19
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq
- Other Designations:
- OTTHUMP00000031848,housekeeping gene, 33kD,peroxisomal farnesylated protein