FITC标记的腺瘤性结肠息肉病蛋白2抗体
产品名称： FITC标记的腺瘤性结肠息肉病蛋白2抗体
英文名称： Anti-APC2/FITC
产品编号： HZ-12485R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-APC2/FITC Conjugated antibody
FITC标记的腺瘤性结肠息肉病蛋白2抗体
| 英文名称 | Anti-APC2/FITC |
| 中文名称 | FITC标记的腺瘤性结肠息肉病蛋白2抗体 |
| 别 名 | Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 细胞粘附分子 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 244kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APCL/APC2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin. Function: APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor. Subunit: Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2. Subcellular Location: Cell Membrane, Cytoplasmic and Golgi Apparatus Tissue Specificity: Widely expressed (at protein level). Specifically expressed in the CNS. Similarity: Belongs to the adenomatous polyposis coli (APC) family. Contains 6 ARM repeats. Database links: Entrez Gene: 29882 Human Entrez Gene: 99152 Mouse Entrez Gene: 296558 Rat Omim: 606946 Human SwissProt: Q9UJX6 Human SwissProt: Q8BZQ7 Mouse Unigene: 434898 Human Unigene: 533262 Human Unigene: 291624 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
腺瘤性息肉病综合征，家族性腺瘤性息肉病（FAP）和加德纳氏综合征（GS），以遍及整个结肠的多个腺瘤性息肉为特征。除了其他的外胚叶表现外，这些息肉总是进展为结肠癌。APC基因的克隆显示一种普遍表达的蛋白质，长度为2843个氨基酸，在FAP和GS患者中经常发生突变。APC已被发现与细胞内连接的结构成分相关。B-连环蛋白和G-连环蛋白（也称为PLAKION）参与细胞粘附的调节。APC和E-cadherin竞争结合B-和G-连环蛋白的特定内部区域。细胞骨架与APC、E-cadherin、B/G连环蛋白复合物的相互作用是由A连环蛋白介导的。