CBL (phospho Y700) polyclonal antibody
产品名称： CBL (phospho Y700) polyclonal antibody
英文名称： CBL (phospho Y700) polyclonal antibody
产品编号： PAB12198
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of CBL.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y700 of human CBL.
- Sequence:
- TEYpMT
- Host:
- Rabbit
- Theoretical MW (kDa):
- 120
- Reactivity:
- Human
- Specificity:
- c-Cbl (phospho-Tyr700) Antibody detects endogenous levels of c-Cbl only when phosphorylated at tyrosine 700.
- Form:
- Liquid
- Purification:
- Immunoaffinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.
Kamei T, Machida K, Nimura Y, Senga T, Yamada I, Yoshii S, Matsuda S, Hamaguchi M.Int J Oncol. 2000 Aug;17(2):335-9.
- 2.
- Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Hunter S, Burton EA, Wu SC, Anderson SM.J Biol Chem. 1999 Jan 22;274(4):2097-106.
- 3.
- c-Cbl: a regulator of T cell receptor-mediated signalling.
Thien CB, Langdon WY.Immunol Cell Biol. 1998 Oct;76(5):473-82.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunofluorescence
- Entrez GeneID:
- 867
- Protein Accession#:
- P22681
- Gene Name:
- CBL
- Gene Alias:
- C-CBL,CBL2,RNF55
- Gene Description:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Omim ID:
- 165360
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
- Other Designations:
- oncogene CBL2